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Benefits of vitamin C in chemotherapy-resistant cancer
Benefits of vitamin C in chemotherapy-resistant cancer
The Department of Translational Oncology of the Fundación Jiménez Díaz in Madrid carried out research on Vitamin C. Its ability to reduce tumor resistance to conventional therapies (chemotherapy) by modulating aberrant metabolism was studied.
The research was managed by the Quirónsalud health group, and its Health Research Institute (IIS-FJD). It was also supported by the Universidad Católica San Antonio de Murcia (UCAM).
The study then detected a surprising and previously unreported role of vitamin C in the regulation of pyruvate dehydrogenase (PDH) activity and its action against the KRAS gene mutation.
Dr Óscar Aguilera, senior research scientist in OncoHealth’s Translational Oncology Department, explained the work:
Vitamin C and chemotherapy resistance
The authors of the study highlight resistance to conventional chemotherapy and anti-EGFR biologic therapies as the major obstacle facing oncology. The approach of new adjuvant treatments, such as Vitamin C, represents a real progression in cure statistics and in the reduction of cancer mortality.
References
Article published in: https://international.ucam.edu/university-news/significant-advances-effectiveness-vitamin-c-treat-persistent-cancers
More information
You can access the medical study at the following link:
Cenigaonandia-Campillo A, Serna-Blasco R, Gómez-Ocabo L, Solanes-Casado S, Baños-Herraiz N, Puerto-Nevado LD, Cañas JA, Aceñero MJ, García-Foncillas J, Aguilera Ó. Vitamin C activates pyruvate dehydrogenase (PDH) targeting the mitochondrial tricarboxylic acid (TCA) cycle in hypoxic KRAS mutant colon cancer. Theranostics 2021; 11(8):3595-3606. doi:10.7150/thno.51265. Available from https://www.thno.org/v11p3595.htm
For more information, you can visit our website.
Recurrent malignant glioma treated with Oncothermia
Recurrent malignant glioma treated with Oncothermia
Through an observational retrospective clinical study, the Onco-Ematology Department of “Ospedali Riuniti Marche Nord” in Italy evaluates the efficacy and tolerability of Oncothermia (Electro-hyperthermia) for the treatment of recurrent malignant glioma.
Method
This is a retrospective observational clinical study. Patients, diagnosed with malignant glioma, experienced a previous failure with chemotherapy and radiotherapy based on temozolamide. Then, they were told a treatment with Oncothermia (Electro-Hyperthermia).
Oncothermia was performed with short radio waves of 13.56 MHz. The surface temperature of the skin was maintained at 26 ° C. Likewise, the applied power ranged between 40 and 150 watts and the average equivalent temperature calculated in the tumors was above 40 ° C, for more than 90% of the duration of the treatment (20-60 minutes gradually).
Result
Of the 24 patients who were part of the study, 19 (79%) had glioblastoma multiforme (GBM), of which 13 were grade 1-3 and 6 grade 4. The remaining patients (21%) had astrocytoma.
The analysis of tumor response performed two months after the application of Oncotermia (Electro-Hyperthermia), showed the following results:
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In conclusion, the treatment of Oncothermia (Electro-Hyperthermia) seems to have promising efficacy in adults with recurrent malignant glioma.
You can consult the study in the following link.
If you wish, you can find more information about Gliomas treated with Oncotermia on our website.
Oncothermia in the treatment of head and neck cancer
Oncothermia in the treatment of head and neck cancer.
Oncothermia treatment applied in conjunction with radiation or chemotherapy can improve efficacy and increase overall and disease-free survival.
In a recent study published by the Department of Radiation, Oncology at Nanavati Hospital in Mumbai, India, led by Dr. Balabhai, assesses the effects of Oncothermia in conjunction with radiation and chemotherapy.
From a retrospective analysis of patients who received paclitaxel or cisplatin together with radical radiation and weekly sessions of Oncothermia, spectacular survival was obtained in advanced head and neck cancer. Similarly, a randomized trial to assess the role of HT with radiation therapy has shown a statistically significant improvement.
Method
Patients were randomized to receive radiotherapy (RT) alone (control group), 26 patients, or radiation with Oncothermia (RT + ONC) (trial group), 28 patients.
The mean age of the patients in the control group was 58.42 years (45-76 years) and in the test group it was 57.71 years (31-78 years).
Patients in both groups received radiation up to a total dose of 70 Gy in 7 weeks with conventional fractionation of 5 days a week, without treatment on weekends. On the other hand, patients in the trial group received weekly RF-based ONC in addition to RT. Twenty-one patients in the control group and twenty-two patients in the experimental group received more than 60 Gy.
Result
Initial response was assessed within 7-10 days after completion of treatment, based on clinical evaluation.
A complete response was observed in 11 of 26 (42.4%) patients in the radiation alone group, while 22 of 28 (78.6%) patients had a complete response in the ONC + RT group.
In conclusion
Oncothermia is a very powerful hypoxic cell sensitizer. Therefore, Oncothermia together with radiation is an ideal combination to follow. The present randomized study, supported by the Indian Council for Medical Research, has shown a survival benefit from adding Oncothermia to radical radiation therapy.
More information
Study published in the Oncothermia Journal, Volume 10, June 2014. To access the full study, you can consult the following link.
If you wish to expand the information regarding Oncotermia applied to cancers, you can visit the following link.
Skin Cancer Treated with Oncothermia and Intravenous Vitamin C
Skin Cancer Treated with Oncothermia and Intravenous Vitamin C
The following is a case report of a 75 year old male patient. The diagnosis is skin cancer. He was treated with oncothermia, combined with intravenous Vitamin C nutrition.
Diagnosis
In April 2019, the patient presented with skin cancer. In particular, a basal cell carcinoma on the left wing of the nose.
Basal cell carcinoma is the most common type of this cancer. It presents in the form of an ulcer with non-healing scabs that progressively increases in size. Treatment consists of surgical resection, leaving the margins free to avoid recurrence.
At the Oncothermia Unit in Barcelona we carry out coadjuvant treatment for these medical cases.
Treatment
Oncothermia and intravenous Vitamin C nutrition are recommended to reduce tumour volume.
Accordingly, she undergoes 15 60-minute Oncothermia sessions, with a frequency of 2 sessions per week, together with intravenous Vitamin C nutrition.
Result:
After completing the treatment the basal cell carcinoma disappeared completely.
If you wish, you can find more information about cancer treated with Oncotermia on our website, you can consult this link.
Oncothermia to Slow Down the Progression and Prevent the Development of Ultimate Pulmonary Fibrosis by COVID-19
Oncothermia to Slow Down the Progression and Prevent the Development of Ultimate Pulmonary Fibrosis by COVID-19
Right now, we are facing a global pandemic caused by the coronavirus SARS-CoV-2 that causes the highly contagious human disease COVID-19. The number of COVID-19 cases is increasing at an alarming rate, more and more people suffer from it, and the death toll is on the rise since December 2019, when COVID-19 has presumably appeared.
Methods
Oncothermia (Modulated electro-hyperthermia, mEHT) is known as an immuno-supportive therapy in oncology. The proposal from a group of scientists from the McGill University, Canada, is to apply this method to prevent the progression of the Pulmonary Fibrosis after its identification, to provide treatment when necessary, and deliver rehabilitation to diminish the fibrotic—often fatal—consequences of the infection.
Hypothesis
The effects of Oncothermia, which are proven for oncological applications, could be utilized for the inactivation of the virus or for treating the fibrotic consequences.
In the other hand, the hypothesized Oncothermia effects, which could have a role in the antiviral treatment, it could be applied for viral-specific immune-activation and for anti-fibrotic treatments.
It´´` is remarcable, that the proposal focuses on the electromagnetic impact, which combines the effects caused by heat and electric field, using their strong synergy. Temperature-dependent and non-temperature dependent factors are combined for optimal treatment. Oncothermia uses the biophysical differences between the malignant and healthy cells to select them and induce apoptotic signals; and immune-mediated abscopal effect.
These method has a long and successful history; it is applied in oncology all over the world.
Radiofrequency current flows into the direction of the lower impedance. (A) The increased metabolic activity of the infected cells allow lower impedance (higher conductance) in their microenvironment than in the healthy cells. (B) The electric field selects the volumes with a high concentration of the infected cells. (C) the lung-lesions are loaded more with the radiofrequency current than the non-infected parts.
Antiviral immune-effect of Oncothermia: the Oncothermia selects the infected cells which release a damage-associated molecular pattern through the process of immunogenic cell-death. The DAMP provides viral genetic information to maturate the dendritic cells producing antigen presentation for T-cells, which turn to viral specific CD4+ CD8+ form. Viral-specific T-cells attack the infected cells in all over the body.
More Information
For more information, you can consult the following link.
If you want more information regarding Oncotermia applied to cancers, you can visit the following link.
Combined treatment of Oncothermia for patients with ovarian cancer
Combined treatment of Oncothermia in Multimodal Immunotherapy.
Ovarian cancer is usually a serious disease with a poor prognosis, mainly due to the spread of the disease before diagnosis. Surgery, chemotherapy and antiangiogenesis are essential for first-line treatment. At the time of relapse or metastasis, only palliative treatments can be performed.
However, Active Specific Immunotherapy has proven capable of prolonging overall survival with a good quality of life.
In the following article, different experiences obtained with ovarian cancer patients treated with Multimodal Immunotherapy have been compiled. That is, injections with the Newcastle Disease Virus (NDV), modulated electrohyperthermia (mEHT / Oncothermia), IO-VAC® and immunomodulatory strategies such as: ATRA, low dose cyclophosphamide or checkpoint blockers.
The treatment was performed on an outpatient basis, with very positive results.
If you wish, you can find more information about ovarian cancer treated with Oncotermia on our website you can check this link.
Clinical study: Oncothermia as a palliative treatment for pancreatic cancer
Clinical study: Oncothermia as a palliative treatment for pancreatic cancer
Retrospective observational study of 106 patients with pancreatic cancer (pancreatic adenocarcinoma) led by Giammaria Fiorentini M.D., of the Onco-Hematology Department of the “Ospedali Riuniti Marche Nord” Hospital in Pesaro, Italy, treated with Oncothermia.
Pancreatic adenocarcinoma is one of the cancers with the poorest prognosis, resulting in a <10% survival rate at 5 years. Modulated electro-hyperthermia (mEHT – Oncothermia) combines heat-therapy with an electric field and has been increasingly used in cancer therapy alone or in combination with radiotherapy and chemotherapy.
Methods
Based on retrospective data from 170 patients affected by stage III-IV pancreatic adenocarcinoma, 106 were considered for this study. The sample was divided into two groups: 67 patients that did not receive Oncothermia (non-MEHT) and 39 patients that were treated with Oncothermia (mEHT).
Oncothermia (mEHT) was performed using a capacitive coupling technique keeping the skin surface at 26°C and 40-42.5°C inside the tumor for > 90% of treatment duration (40-90 minutes). The applied power was 60-150 Watts. Oncothermia was performed in association with chemotherapy in 32 (82%) of patients whereas 7 (18%) received Oncothermia alone. The majority (54%) of no-mEHT group received a second line chemotherapy, whereas 31 (46%) did not receive any further treatment.
Results
106 consecutive patients were enrolled in this study, median age of the sample was 65 (range 31-80) years.
After three months of therapy, tumor response in Oncothermia group was:
Tumor response in no-Oncothermia group was:
The median overall survival (OS) of mEHT group was 17.23 (range 2.6-30.4) and 11,33 months (range 0.4-56.25) for non-mEHT group.
In conclusion, Oncothermia may improve tumor response and survival of pancreatic cancer patients.
More information about the study in the following link.
More information about pancreatic cancer treated with Oncothermia on our website (link) or in the following clinical case.
Elevated apoptosis in a radioresistant pancreatic adenocarcinoma cell line
Elevated apoptosis and tumor stem cell destruction in a radioresistant pancreatic adenocarcinoma cell line
A recent study presented by Gertrud Farika, from the 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary. It deals with elevated apoptosis and tumor stem cell destruction in a radioresistant pancreatic adenocarcinoma cell line when radiotherapy is combined with modulated electro-hyperthermia (mEHT- Oncothermia)
Malignant exocrine tumors of the pancreas are among the worst to respond to oncotherapy. Despite sophisticated guidelines and new targeted therapies, the 5-year survival rate of patients with pancreatic adenocarcinomas is under 10%. The most critical factor responsible for this is the high resistance of the tumor cells to the available chemo- or radiotherapies.
Oncothermia (Modulated electro-hyperthermia – mEHT) is a complementary non-invasive cancer treatment using impedance-coupled radiofrequency to generate selective heat of <42°C causing cell stress and destruction in malignant tissue. In this study, we tested the combination of radiotherapy with Oncothermia in a radioresistant pancreatic adenocarcinoma cell line Panc1.
Methods
The study was organizated in 4 groups:
Results
Visible morphological changes were observed after 24 hours in the treated groups. An elevated number of apoptotic bodies and cell number loss were appeared. Compared to the control group, the apoptotic ratio was the highest in the Oncothermia +R group and significant elevation was measured also in the Oncothermia group. ALDH+ tumor stem cells decreased significantly after Oncothermia and Oncothermia +R treated groups compared to the control.
As it was expected the irradiated group showed the same amount
of CSC cells as the control group (due to well-known radioresistance of the cell line). The CSCs colony forming capacity was also significantly lower in the Oncothermia and Oncothermia +R group compared to the control group. Furthermore, H2Axγ and calreticulin positive cell fractions, indicating DNA double strand-brakes and ER-stress, respectively, were also significantly increased in the Oncothermia and the Oncothermia +R treated groups.
Apoptosis with Oncothermia
Oncothermia treatment alone can lead to massive apoptosis in Panc1 cells by inducing cell stress and DNA double-strand break. Irradiation alone caused some necrosis but without major effect on CSCs. The combined treatment significantly improved the efficacy of radiotherapy resulting in major apoptosis and reduction of CSCs despite of the inherent radioresistance of Pan1.
This study was funded by a grant of the National Research and Innovation Office.
For more information, you can access the original study in the following link.
Malignant peripheral nerve sheath tumour treated with Oncothermia
Malignant peripheral nerve sheath tumour treated with Oncothermia
The following is the clinical case of a 70-year-old male patient. The diagnosis is malignant peripheral nerve sheath tumour in the left buttock. He was treated with radiotherapy, combined with oncothermia.
Diagnosis
In September 2012 he was diagnosed with a malignant peripheral nerve sheath tumour in the buttock.
Treatment
He received radiotherapy of 30 Gy in 10 fractions over 2 weeks in September 2012. Overall, after radiotherapy the tumour remained in progress for 2 months.
Oncothermia was started 2-3 times per week as an adjunct to radiotherapy.
Result
The tumour regressed with oncothermia treatment and this process continued gradually when oncothermia was maintained for 1 year.
(a) Radiotherapy treatment
(b) Radiation therapy and 24 sessions of Oncothermia
(c) Treatment with radiotherapy and 48 sessions of Oncothermia
(d) Treatment with radiotherapy and 72 sessions of Oncothermia
(e) Treatment with radiotherapy and 108 sessions of Oncothermia (1 year after starting treatment).
Reference
Jeung, T. , et al. (2015) Results of Oncothermia Combined with Operation, Chemotherapy and Radiation Therapy for Primary, Recurrent and Metastatic Sarcoma. Case Reports in Clinical Medicine, 4, 157-168. doi: 10.4236/crcm.2015.45033.
If you wish, you can find more information about clinical cases treated with Oncotermia on our website.
Oncothermia EHY-2000: Latest technology
Oncothermia EHY-2000: Latest technology
Oncological Nanothermia or Oncothermia is a non-invasive modulated electromagnetic hyperthermia method, adjuvant in cancer treatment, which promotes a natural regulatory process of the body.
The Oncotherm® brand was founded in 1988 by Professor Dr. András Szász, as an initiative for the development and research of the electro-hyperthermia method in cancer treatment.
The latest generation model in Oncothermia is: EHY-2000. Currently there are other models of devices, but they do not guarantee the results obtained and investigated by Dr. András Szász.
At the Barcelona Oncothermia Unit you will find the latest technology to offer you the best results.