brain tumour archivos - Clínica Oncología Integrativa. Nanotermia. Oncothermia

CLINICAL CASE 5:

• BRAIN TUMOR (GLIOBLASTOMA)
• CHEMOTHERAPY + ONCOTHERMIA

A 60-year-old male presented a brain tumor in the left hemisphere in April 2016, showing the biopsy a high-grade glioblastoma multiforme inoperable by size. In July 2016 begins radiotherapy and chemotherapy with temozolamide coinciding with significant clinical worsening, tumor progression and increase in the number of epileptic seizures with more than 7 episodes a day. The patient had a significant decrease in the state of consciousness, total aphasia and right hemiparesis. Given the significant deterioration suffered by the treatment and tumor progression, evicted and without therapeutic options, the family rejects palliative treatment of chemotherapy and decide to perform treatment with oncothermia. In September 2016, she started treatment with oncothermia 60 minutes, 2-3 times / week continuously with some rest periods until March 2018. Throughout the treatment he has shown clinical improvement with improvement of aphasia and coordination. Until March 2018 without tumor progression.

Prof. Giammaria Fiorentini of the Department of Onco-Hematology of Azienda Ospedaliera Marche Nord, Pesaro, Italy, presented at the 35th Annual Conference of the International Clinical Hyperthermia Society (ICHS) in Guangzhou, the results of their work in the treatment with Hyperthermia (Oncothermia) in patients with brain tumors.

The study was carried out with an Oncotherm EHY-2000 PLUS device, on 24 patients: 19 with glioblastoma multiforme and 5 with astrocytoma. All of them were previously treated with surgery, TMZ chemotherapy and radiotherapy.

Through the article Prof. Giammaria Fiorentini describes the characteristics of brain tumors, their incidence and mortality, survival and conventional therapies that are used, with an emphasis on the case of Glioblastoma and the benefits obtained by applying Electro-hyperthermia.

According to his observations Oncothermia (Electro-hyperthermia) is a non-invasive treatment, without toxicity and feasible to treat recurrent malignant gliomas, which allows to increase the response to the tumor and the survival of the patient.

The full article can be accessed by visiting this link.

Hypothesis: Studies that observe the effectiveness of Hyperthermia in HG Gliomas.

Oncothermia (Electro – Hyperthermia) traslational studies.

Oncothermia application in malignant gliomas.

Study on the activity and toxicity of Oncothermia in recurrent malignant gliomas.

Description of the equipment used: Oncotherm EHY-2000 PLUS, non-ionizing therapy that elevates the temperature of the tumor macro and micro-enviroments, to a range of 40-45ºC, generating a 40-150 Watt radiofrequency, at 13.56 MHz.

24 patients, 19 with glioblastoma multiforme and 5 with astrocytoma. All patient were pre-treated with surgery, chemotherapy and radiotherapy.

Oncothermia treatment: 3 sessions/week for 4 weeks, 20 a 60 minutes each session.

Results: 2 complete remissions and 5 partial remissions were observed. The medial OS was 14 months for gliomas and 61 months for astrocitomas.