Oncothermia

First, Oncothermia is an adjuvant treatment against cancer.

Oncothermia treatment promotes a natural regulatory process in the body. Also, It inhibits the natural activity of malignant cells.

And, Oncothermia is indicated for: primary tumours, brain tumours, gynaecological tumours, metastases, lymphomas and melanomas.

It is a non-invasive method. It has hardly any contraindications.

Tag Archive for: Oncothermia

Benefits of vitamin C in chemotherapy-resistant cancer

Benefits of vitamin C in chemotherapy-resistant cancer

The Department of Translational Oncology of the Fundación Jiménez Díaz in Madrid carried out research on Vitamin C. Its ability to reduce tumor resistance to conventional therapies (chemotherapy) by modulating aberrant metabolism was studied.

The research was managed by the Quirónsalud health group, and its Health Research Institute (IIS-FJD). It was also supported by the Universidad Católica San Antonio de Murcia (UCAM).

The study then detected a surprising and previously unreported role of vitamin C in the regulation of pyruvate dehydrogenase (PDH) activity and its action against the KRAS gene mutation.

Dr Óscar Aguilera, senior research scientist in OncoHealth’s Translational Oncology Department, explained the work:

“We think that metabolic modulation of the tumor can make it much more sensitive to chemotherapy and could significantly increase patients’ life expectancy and improve their quality of life.”

“The almost complete absence of serious side effects of vitamin C in megadoses invites clinical trials with patients in combination with various pharmaceutical molecules of interest.”

Vitamin C and chemotherapy resistance

The authors of the study highlight resistance to conventional chemotherapy and anti-EGFR biologic therapies as the major obstacle facing oncology. The approach of new adjuvant treatments, such as Vitamin C, represents a real progression in cure statistics and in the reduction of cancer mortality.

References

Article published in: https://international.ucam.edu/university-news/significant-advances-effectiveness-vitamin-c-treat-persistent-cancers

More information

You can access the medical study at the following link:

Cenigaonandia-Campillo A, Serna-Blasco R, Gómez-Ocabo L, Solanes-Casado S, Baños-Herraiz N, Puerto-Nevado LD, Cañas JA, Aceñero MJ, García-Foncillas J, Aguilera Ó. Vitamin C activates pyruvate dehydrogenase (PDH) targeting the mitochondrial tricarboxylic acid (TCA) cycle in hypoxic KRAS mutant colon cancer. Theranostics 2021; 11(8):3595-3606. doi:10.7150/thno.51265. Available from https://www.thno.org/v11p3595.htm

For more information, you can visit our website.

Recurrent malignant glioma treated with Oncothermia

Recurrent malignant glioma treated with Oncothermia

Through an observational retrospective clinical study, the Onco-Ematology Department of “Ospedali Riuniti Marche Nord” in Italy evaluates the efficacy and tolerability of Oncothermia (Electro-hyperthermia) for the treatment of recurrent malignant glioma.

Method

This is a retrospective observational clinical study. Patients, diagnosed with malignant glioma, experienced a previous failure with chemotherapy and radiotherapy based on temozolamide. Then, they were told a treatment with Oncothermia (Electro-Hyperthermia).

Oncothermia was performed with short radio waves of 13.56 MHz. The surface temperature of the skin was maintained at 26 ° C. Likewise, the applied power ranged between 40 and 150 watts and the average equivalent temperature calculated in the tumors was above 40 ° C, for more than 90% of the duration of the treatment (20-60 minutes gradually).

Result

Of the 24 patients who were part of the study, 19 (79%) had glioblastoma multiforme (GBM), of which 13 were grade 1-3 and 6 grade 4. The remaining patients (21%) had astrocytoma.

The analysis of tumor response performed two months after the application of Oncotermia (Electro-Hyperthermia), showed the following results:

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  • 2 patients (8%) experienced a complete remission
  • 5 patients (21%) had a partial remission.
  • The average duration of the response was 16 months (range 6-120).

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The median survival of the entire study population was 19.5 months (range 2-156), with 55% survival rate per year and 15% at two years.

In conclusion, the treatment of Oncothermia (Electro-Hyperthermia) seems to have promising efficacy in adults with recurrent malignant glioma.

You can consult the study in the following link.

If you wish, you can find more information about Gliomas treated with Oncotermia on our website.

Oncothermia in the treatment of head and neck cancer

Oncothermia in the treatment of head and neck cancer.

Oncothermia treatment applied in conjunction with radiation or chemotherapy can improve efficacy and increase overall and disease-free survival.

In a recent study published by the Department of Radiation, Oncology at Nanavati Hospital in Mumbai, India, led by Dr. Balabhai, assesses the effects of Oncothermia in conjunction with radiation and chemotherapy.

From a retrospective analysis of patients who received paclitaxel or cisplatin together with radical radiation and weekly sessions of Oncothermia, spectacular survival was obtained in advanced head and neck cancer. Similarly, a randomized trial to assess the role of HT with radiation therapy has shown a statistically significant improvement.

Due to high tobacco use, head and neck cancers constitute a significant burden of all cancers in Indian men.

Method

Patients were randomized to receive radiotherapy (RT) alone (control group), 26 patients, or radiation with Oncothermia (RT + ONC) (trial group), 28 patients.

The mean age of the patients in the control group was 58.42 years (45-76 years) and in the test group it was 57.71 years (31-78 years).

Patients in both groups received radiation up to a total dose of 70 Gy in 7 weeks with conventional fractionation of 5 days a week, without treatment on weekends. On the other hand, patients in the trial group received weekly RF-based ONC in addition to RT. Twenty-one patients in the control group and twenty-two patients in the experimental group received more than 60 Gy.

Result

Initial response was assessed within 7-10 days after completion of treatment, based on clinical evaluation.

A complete response was observed in 11 of 26 (42.4%) patients in the radiation alone group, while 22 of 28 (78.6%) patients had a complete response in the ONC + RT group.

The difference between the mean survival times between the RT + ONC and RT groups was almost 100 days.

In conclusion

Oncothermia is a very powerful hypoxic cell sensitizer. Therefore, Oncothermia together with radiation is an ideal combination to follow. The present randomized study, supported by the Indian Council for Medical Research, has shown a survival benefit from adding Oncothermia to radical radiation therapy.

In conclusion, both the randomized trial and the retrospective data analysis demonstrate a significant improvement in survival due to the addition of Oncothermia.

More information

Study published in the Oncothermia Journal, Volume 10, June 2014. To access the full study, you can consult the following link.

If you wish to expand the information regarding Oncotermia applied to cancers, you can visit the following link.

Skin Cancer Treated with Oncothermia and Intravenous Vitamin C

Skin Cancer Treated with Oncothermia and Intravenous Vitamin C

The following is a case report of a 75 year old male patient. The diagnosis is skin cancer. He was treated with oncothermia, combined with intravenous Vitamin C nutrition.

Diagnosis

In April 2019, the patient presented with skin cancer. In particular, a basal cell carcinoma on the left wing of the nose.

Basal cell carcinoma is the most common type of this cancer. It presents in the form of an ulcer with non-healing scabs that progressively increases in size. Treatment consists of surgical resection, leaving the margins free to avoid recurrence.

At the Oncothermia Unit in Barcelona we carry out coadjuvant treatment for these medical cases.

Treatment

Oncothermia and intravenous Vitamin C nutrition are recommended to reduce tumour volume.

Accordingly, she undergoes 15 60-minute Oncothermia sessions, with a frequency of 2 sessions per week, together with intravenous Vitamin C nutrition.

Result:

After completing the treatment the basal cell carcinoma disappeared completely.

If you wish, you can find more information about cancer treated with Oncotermia on our website, you can consult this link.

Elevated apoptosis in a radioresistant pancreatic adenocarcinoma cell line

Elevated apoptosis and tumor stem cell destruction in a radioresistant pancreatic adenocarcinoma cell line

A recent study presented by Gertrud Farika, from the 1st Department of  Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary. It deals with elevated apoptosis and tumor stem cell destruction in a radioresistant pancreatic adenocarcinoma cell line when radiotherapy is combined with modulated electro-hyperthermia (mEHT- Oncothermia)

Malignant exocrine tumors of the pancreas are among the worst to respond to oncotherapy. Despite sophisticated guidelines and new targeted therapies, the 5-year survival rate of patients with pancreatic adenocarcinomas is under 10%. The most critical factor responsible for this is the high resistance of the tumor cells to the available chemo- or radiotherapies.

Oncothermia (Modulated electro-hyperthermia – mEHT) is a complementary non-invasive cancer treatment using impedance-coupled radiofrequency to generate selective heat of <42°C causing cell stress and destruction in malignant tissue. In this study, we tested the combination of radiotherapy with Oncothermia in a radioresistant pancreatic adenocarcinoma cell line Panc1.

Methods

The study was organizated in 4 groups:

  • control (C)
  • Oncothermia treated for 60 min (mEHT)
  • irradiated with 2 Gy using 137Cs (R)
  • combination treatment: irradiation followed by the same dose of Oncothermia (Oncothermia +R)

Results

Visible morphological changes were observed after 24 hours in the treated groups. An elevated number of apoptotic bodies and cell number loss were appeared. Compared to the control group, the apoptotic ratio was the highest in the Oncothermia +R group and significant elevation was measured also in the Oncothermia group. ALDH+ tumor stem cells decreased significantly after Oncothermia and Oncothermia +R treated groups compared to the control.

As it was expected the irradiated group showed the same amount
of CSC cells as the control group (due to well-known radioresistance of the cell line). The CSCs colony forming capacity was also significantly lower in the Oncothermia and Oncothermia +R group compared to the control group. Furthermore, H2Axγ and calreticulin positive cell fractions, indicating DNA double strand-brakes and ER-stress, respectively, were also significantly increased in the Oncothermia and the Oncothermia +R treated groups.

Apoptosis with Oncothermia

Oncothermia treatment alone can lead to massive apoptosis in Panc1 cells by inducing cell stress and DNA double-strand break. Irradiation alone caused some necrosis but without major effect on CSCs. The combined treatment significantly improved the efficacy of radiotherapy resulting in major apoptosis and reduction of CSCs despite of the inherent radioresistance of Pan1.

This study was funded by a grant of the National Research and Innovation Office.

For more information, you can access the original study in the following link.

Malignant peripheral nerve sheath tumour treated with Oncothermia

Malignant peripheral nerve sheath tumour treated with Oncothermia

 

The following is the clinical case of a 70-year-old male patient. The diagnosis is malignant peripheral nerve sheath tumour in the left buttock. He was treated with radiotherapy, combined with oncothermia.

 

Diagnosis

In September 2012 he was diagnosed with a malignant peripheral nerve sheath tumour in the buttock.

 

Treatment

He received radiotherapy of 30 Gy in 10 fractions over 2 weeks in September 2012. Overall, after radiotherapy the tumour remained in progress for 2 months.

Oncothermia was started 2-3 times per week as an adjunct to radiotherapy.

 

Result

The tumour regressed with oncothermia treatment and this process continued gradually when oncothermia was maintained for 1 year.

 

 

(a) Radiotherapy treatment
(b) Radiation therapy and 24 sessions of Oncothermia
(c) Treatment with radiotherapy and 48 sessions of Oncothermia
(d) Treatment with radiotherapy and 72 sessions of Oncothermia
(e) Treatment with radiotherapy and 108 sessions of Oncothermia (1 year after starting treatment).

 

Reference

Jeung, T. , et al. (2015) Results of Oncothermia Combined with Operation, Chemotherapy and Radiation Therapy for Primary, Recurrent and Metastatic Sarcoma. Case Reports in Clinical Medicine, 4, 157-168. doi: 10.4236/crcm.2015.45033.

 

If you wish, you can find more information about clinical cases treated with Oncotermia on our website.

Clinical trials: Oncothermia and Cancer

Ensayos clínicos: Oncothermia y Cáncer

Clinical trials: Oncothermia and Cancer.

Oncothermia is an active part of current medical research. There are several Clinical Trials, in patients with cancer, performed in different hospitals around the world.

Clinical trials are a basic tool for the development of drugs and medical devices, in order to improve the current treatment of diseases and develop health tools worldwide.

Clinicaltrials.gov is an internationally recognized web page, where researchers publish the latest clinical trials that are carried out in different hospitals around the world. Oncothermia is present on this website. We will inform you about the latest advances in Oncothermia and Cancer.

Clinical study of Oncothermia applied to a patient with malignant ascites

The clinical study “Oncothermia + intraperitoneal chemotherapy in malignant ascites: Phase II” (Local mEHT * + TCM Versus Intraperitoneal Chemoinfusion in Treatment of Malignant Ascites: Phase II RCT (OTMA-RII) of Prof. Pang, Clifford Hospital, Guangzhou, China) began to include patients in January 2014 and ended in March 2016. The research included two groups of 130 patients. The “experimental group” will be treated with: diet, Chinese herbal medicine and Oncothermia. Instead, the “control group” will be treated with chemotherapy.

We will be attentive to the conclusions of the study!

* Clinical trial “Oncothermia + intraperitoneal chemotherapy in malignant ascites: Phase II“

Oncothermia in combination with Radiotherapy exerts a radiosensitizing effect in lung cancer.

efecto radiosensibilizante en el Cáncer de PulmónOncothermia in combination with Radiotherapy exerts a radiosensitizing effect in lung cancer.

The sensitivity of tumors to radiotherapy and chemotherapy is increased by Oncothermia.

Oncothermia, also known as electro-hyperthermia, is a new treatment modality that allows for increased sensitivity to other treatments. It has been developed to overcome the problems of traditional hyperthermia by targeting malignant tissues.

A study was published in 2015 in the journal Experimental and Therapeutic Medicine. It reports the outcome of combined oncothermia and RT in a 75-year-old patient with stage IIIB non-small-cell lung cancer (NSCLC).

Due to the advanced age and the performance status of the patient, the combination of systemic chemotherapy and RT was deemed infeasible. Therefore, the patient instead decided to undergo oncothermia concurrently with definitive RT.

The RT was administered at a dose of 64.8 Gy in 36 fractions using a three-dimensional conformal plan technique. In this case, Oncothermia was started concomitantly with RT. And was performed for 60 min per session, two sessions per week, for a total of 12 sessions.

Follow-up computed tomography showed complete tumor response. And the patient was alive with no evidence of the disease 18 months after the completion of the treatment.

In conclusion, the present case report suggests that oncothermia combined with RT has former possessing radiosensitizing potential and no additional toxicities. May be it is a promising alternative for advanced-age and/or frail patients with locally advanced NSCLC.

In addition, you can find more information about lung cancer on our website.

Effect of Oncothermia at the cellular level. Study in colorectal cancer xenografts

Effect of Oncothermia at the cellular level. Study in colorectal cancer xenografts

Researchers studied the effect of Oncothermia at the cellular level in the process of apoptosis in colorectal cancer cells.

The Department of Radiology of the Medicine and Pharmacy Faculty -University of Toyama, in Toyama, Japan- published in the journal CellStress and Chaperones (Springer) (Cell Stress Chaperones, 2015 Jan; 20 (1): 37-46 ) the results on the effect of Oncothermia in colorectal cancer cells.

Cell apoptosis

First of all, the use of modulated electrohyperthermia (mEHT) or Oncothermia, produces a modification of the electric field and the surrounding temperature of the tumor cell, leading to selective cell death (apoptosis) in malignant tumors without affecting healthy tissue. Certainly, this is possible due to the difference of a tumor cell compared with a healthy cell. Also, the tumor cell is characterized by high glycolysis, increased lactate production (Warburg effect) and reduced electrical impedance.

Oncothermia applied to colorectal cancer

Dr Andocs studied the effect of Oncothermia on HT29 xenografts of colorectal cancer (human colon cancer cells, inoculated in mice). Apoptosis caused by Oncothermia was mediated, predominantly, by the caspase cascade and the activation of the apoptosis inducing factor. The mEHT-related cell stresses studied 0-, 1-, 4-, 8-, 14-, 24-, 48-, 72-, 120-, 168- and 216-h. And post-treatment by focusing on damage-associated molecular pattern (DAMP) signals.

 Apoptosis response was after 4 hours from the treatment with Oncothermia. It was measured using the levels of messenger RNA (mRNA) levels of the “heat shock” proteins Hsp70 and Hsp90.

Results

After that, the treatment resulted in spatiotemporal occurrence of a DAMP protein signal sequence featured by the significant cytoplasmic to cell membrane translocation of calreticulin at 4 h, Hsp70 between 14 and 24 h and Hsp90 between 24- and 216-h post-treatment.

Also, the release of high-mobility group box1 protein (HMGB1) from tumor cell nuclei from 24-h post-treatment and its clearance from tumor cells by 48 h was also detected.

Conclusion

In conclusion, the results suggest that mEHT treatment can induce a DAMP-related signal sequence in colorectal cancer xenografts that may be relevant for promoting immunological cell death response, which need to be further tested in immune-competent animals.

To conclude, the next experimental phase, which is to replicate the study in immunocompetent animals, is necessary.

Further information

If you would like further information on Oncothermia applied to colon cancer, please visit the following link.

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Oncothermia at the Congress of Radiotherapy Technicians (10-12 / 11/2017, Lisbon, Portugal)

Oncothermia at the Congress of Radiotherapy Technicians (10-12 / 11/2017, Lisbon, Portugal)

Filipe Cidade de Moura and Prof.András Szász

Oncothermia is an adjuvant treatment for cancer. It is present at an international level at events such as this congress and other conferences. At these scientific meetings, doctors, technicians and healthcare personnel give presentations to disseminate the results of clinical cases.

Congress in Lisboa

Therefore, on November 10-12, 2017, in Lisbon, took place the Congress of Radiotherapy Technicians (Congresso 2017art).

The congress was organized in different sections. Professor Szasz led the talk “Immunological effects with Oncothermia“, where he presented his latest research and results. Also, he detailed his studies on Oncothermia and the results in relation to the inhibitory effect on the natural activity of the malignant cells. Among other things he highlighted the stimulation of the patient’s immune response.

Objective of the research

Most of the radiation therapies act locally. The local control of the tumor is usually not enough for elongation of the survival time because the malignancy is systemic. The abscopal effect, together with immune-stimuli could extend the local method to systemic and could be effective against macro- and micrometastases, too. Our objective is presenting the abscopal effect of modulated electro-hyperthermia (mEHT, oncothermia).

References

https://www.justnews.pt/documentos/2015/image/file/17e/ProgramaCNART-2017.pdf

http://oncotherm.com/en/news-events/congresso-2017-art-profandras-szasz-was-invited-hold-lecture